|
|
Photomicrograph showing immunostaining for smooth muscle actin (SMA). Animals that had received 100 ppb arsenic exposures during development had apparent increases in SMA around airways (A).
|
Background
While arsenic has long been recognized as a human carcinogen, the non-cancerous health effects of arsenic ingestion in the drinking water can also lead to significant disease, including cardiovascular disease, arteriosclerosis, diabetes and chronic pulmonary disease. The effects of in utero or early postnatal exposure on alterations in development, leading to non-cancerous health effects, have not been studied.
Goal
To evaluate the developmental effects of arsenic in the lung and the effect of folate on these developmental effects.
Objectives
1. Determine the dose response of arsenic-induced altered gene expression in fetal and neonatal lung.
2. Correlate altered expression with phenotype.
3. Assess effects of folic acid deficiency and supplementation on alteration of gene expression and phenotype induced by exposure to arsenic.
Project 4 publications resulting
from research conducted under the Superfund Research Program
during the grant funding period of 2005 to present.
Contact
Clark Lantz
lantz@email.arizona.edu
(520) 626-6716 |
